Antibody binds to PEG-ylated compounds and macromolecules, free PEG. Antibody binds to PEG chain, not to the end group of the PEG polymer. Specificity of the product has been determined by ELISA against PEG-ylated proteins.
Armstrong JK. The occurrence, induction, specificity, and potential effect of antibodies against poly(ethylene glycol). In "PEGylated Protein Drugs: Basic Science and Clinical Applications. FM Veronese, editor. Birkhauser Verlag, Switzerland, 2009.
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